Exmere

    Silica family

    Exsil 80

    High-surface-area 80 Å spherical silica for demanding small-molecule HPLC.

    80 Å230 m²/g1.5 µm – 10 µmType A, high-purity
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    Exsil 80 spherical silica microspheres
    Fully spherical · 80 Å · 1.5 – 10 µm

    Pore size

    80 Å

    Surface area

    230 m²/g

    Pore volume

    0.5 mL/g

    Particle sizes

    1.5 µm – 10 µm

    Morphology

    Fully spherical

    pH range

    2 – 8

    What is Exsil 80

    Spherical, high-surface-area silica engineered for reproducible HPLC.

    Exsil 80 is a fully spherical, high-purity Type A silica designed as a base material for reversed-phase, normal-phase and ion-exchange HPLC of small molecules. It is used by column manufacturers and preparative labs that need a consistent silica across analytical, UHPLC and preparative particle sizes.

    Because Exsil 80 is manufactured from the same base silica across all particle sizes, methods developed on the 5 µm analytical grade transfer predictably to the 1.5 µm UHPLC grade and up to the 10 µm preparative grade — with the same selectivity, the same bonded-phase chemistries and the same trace-metal profile.

    Why choose Exsil 80

    Why chromatographers choose Exsil 80.

    High surface area

    230 m²/g provides the retention capacity needed for small-molecule reversed-phase and normal-phase separations.

    Reproducible chemistry

    Tight batch-to-batch specification on pore volume, surface area and metals.

    Full particle spectrum

    1.5 – 10 µm from a single silica lineage — analytical to preparative.

    UK-manufactured in bulk

    Manufactured to kilogram and hundreds-of-kilograms scale in Carnforth, UK.

    Broad bonded-phase range

    ODS, ODS-1, C8, C6, Phenyl, NH₂, CN, SAX and custom chemistries.

    Where it fits

    Applications Exsil 80 is designed for.

    Pharma QC & impurity profiling

    USP-compliant reversed-phase methods for APIs and finished products.

    Method development

    High retention makes it the workhorse for scouting non-polar analytes.

    Bioanalysis

    1.5 µm grade enables fast UHPLC methods for bioanalytical screening.

    Natural products & food

    Flavonoids, alkaloids, polyphenols on ODS/Phenyl chemistries.

    Ion exchange

    SAX bonding for organic acid and nucleotide analysis.

    Preparative purification

    10 µm bulk grade for gram-to-kilogram isolation.

    Performance evidence

    Performance evidence

    Method-transfer comparison against Spherisorb®, plus batch-to-batch physical-property data. Full application notes and raw data available on request.

    Four-panel chromatogram comparing Exsil 80 and Spherisorb® 5 µm NH₂ and Phenyl columns, showing matched selectivity, retention and peak shape.

    Application note

    Chromatographic comparison with Spherisorb®

    Side-by-side separations on Exsil 80 and Spherisorb® 5 µm NH₂ and Phenyl columns show highly comparable selectivity, retention behaviour and peak shape. Established Spherisorb® methods transfer to Exsil 80 with minimal re-optimisation.

    • Comparable selectivity
    • Matching retention behaviour
    • Straightforward method transfer
    Batch-to-batch consistency of Exsil 80 surface area, pore volume and pore diameter across nine production batches

    Quality data

    Batch-to-batch consistency — physical properties

    Surface area, pore volume and pore diameter measured across nine consecutive Exsil 80 production batches. Values remain within tight tolerances, supporting reproducible column performance.

    Full specification

    Engineered properties.

    Mean particle size1.5 µm, 3 µm, 5 µm, 10 µm
    Particle-size distributiond90/d10 ≤ 1.5
    Pore size80 Å (± 10 %)
    Specific surface area230 m²/g (± 20)
    Pore volume0.5 mL/g
    Trace metals (Fe, Al)< 20 ppm each
    pH operating range2 – 8
    Silanol activityType A (acidic)

    Full Certificate of Analysis and detailed characterisation data (BET, mercury porosimetry, ICP-MS trace metals, PSD) available on request.

    Bonded phases

    Available Exsil 80 chemistries.

    Every phase is offered in both endcapped and non-endcapped versions. Custom bondings on request.

    Reversed Phase

    • ODS (C18)
    • ODS-1 (C18, low coverage)
    • C8
    • C6
    • Phenyl

    Normal Phase / HILIC

    • Bare Silica
    • NH₂
    • CN

    Ion Exchange

    • SAX
    Explore full bonded-phase portfolio

    Sizes & formats

    From UHPLC to process scale.

    Particle sizeTypical useAvailability
    1.5 µmUHPLC — fast analytical
    Analytical
    3 µmHigh-throughput analytical
    Analytical
    5 µmRoutine HPLC / QC workhorse
    Analytical + semi-prep
    10 µmPreparative / process scale
    Preparative & bulk

    Scale-up

    Same silica, every scale.

    1.5 µm

    UHPLC screen

    3 – 5 µm

    Analytical method

    10 µm

    Semi-prep

    10 µm bulk

    Process scale

    Because every particle size shares the same base silica synthesis and bonding process, selectivity and retention translate predictably across scales — no re-development when moving from method screening to production.

    Why buy from Exmere

    A silica manufacturer that does not compete with its customers.

    Bulk silica specialist

    40+ years of manufacturing HPLC silica in the UK. We supply the bulk material — you own the finished product.

    OEM neutral

    Column-packing customers can specify Exsil without competitive risk.

    Analytical to process scale

    The same silica lineage from R&D samples through to hundreds of kilos — no supplier changes as you scale.

    FAQ

    Frequently asked questions.

    Next step

    Talk to us about Exsil 80.

    Request a technical sample, a full CoA, or a quotation for bulk supply. A chromatography specialist will respond within one business day.

    Free technical evaluation samples

    Full CoA and characterisation data

    OEM & private-label supply

    Response within one business day

    Exmere Ltd — HPLC Silica Engineering

    Unit 8, Boundary Way, Kellet Road Industrial Estate, Carnforth, Lancashire LA5 9XP, UK

    info@exmere.eu · +44 (0)1524 734451