Exmere

    Base-deactivated HPLC silica

    Exsil Avanti BDS

    Base-deactivated silica for outstanding peak symmetry of basic compounds.

    Exsil Avanti BDS is a premium Type B silica developed for laboratories and manufacturers working with basic analytes. Its carefully controlled base-deactivated surface minimises secondary silanol interactions to deliver excellent peak symmetry, robust separations and reliable long-term performance.

    145 Å190 m²/g1.5 µm – 10 µmType B
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    Exsil Avanti BDS base-deactivated spherical silica microspheres
    Base-deactivated · 145 Å · 1.5 – 10 µm

    Pore size

    145 Å

    Surface area

    190 m²/g

    Morphology

    Fully spherical

    Particle sizes

    1.5 µm – 10 µm

    Silica type

    Type B, base-deactivated

    pH range

    2 – 8

    What is Exsil Avanti BDS

    Base-deactivated silica engineered for basic compounds.

    Exsil Avanti BDS is a fully spherical Type B HPLC silica with 145 Å pore diameter and 190 m²/g specific surface area. Its base-deactivated surface is designed to reduce the residual silanol interactions that cause peak tailing and unpredictable retention for basic analytes.

    The full bonded-phase portfolio is available across 1.5 µm to 10 µm from a single silica lineage, so methods for basic APIs, amines and alkaloids scale predictably from UHPLC screening through routine QC to preparative isolation.

    Why Exsil Avanti BDS

    Why chromatographers choose Exsil Avanti BDS.

    Base-deactivated silica surface

    A controlled base-deactivation process reduces residual silanol interactions on the silica surface.

    Reduced silanol activity

    Lower silanol activity minimises unwanted secondary interactions with protonated basic analytes.

    Excellent peak symmetry for basic compounds

    Delivers symmetrical peaks and reduced tailing for amines, alkaloids and basic APIs.

    Suitable for analytical and preparative HPLC

    Available from 1.5 µm UHPLC particles through to 10 µm preparative grades.

    Reliable batch-to-batch consistency

    Physical properties held to tight release specifications and reported on the CoA.

    Manufactured by Exmere

    Produced in the UK by Exmere under a controlled process suited to long-term supply.

    The chemistry

    Why base-deactivated silica?

    Basic analytes place unusual demands on HPLC silica. Here is what happens on a conventional surface — and how base deactivation changes the picture.

    On the surface of any HPLC silica sit residual silanol groups (Si–OH). When a basic compound becomes protonated in the mobile phase, these silanols can interact with it through ion exchange and hydrogen bonding — in addition to the intended reversed-phase retention on the bonded ligand.

    These secondary interactions often lead to:

    • Peak tailing
    • Reduced efficiency
    • Lower robustness across columns, batches and mobile-phase conditions

    Base deactivation is a controlled surface treatment that significantly reduces these unwanted interactions while maintaining the chromatographic performance expected from a modern Type B silica.

    In plain terms

    Less silanol activity, better peak shape.

    A base-deactivated silica behaves more predictably with basic analytes: peaks stay symmetrical, retention is easier to reproduce between batches, and methods survive routine mobile-phase and pH changes with fewer surprises.

    Technical characteristics

    Engineered properties.

    Mean particle size1.5 µm, 3 µm, 5 µm, 10 µm
    Pore size145 Å
    Specific surface area190 m²/g
    MorphologyFully spherical
    Silica typeType B, base-deactivated
    pH operating range2 – 8

    Full Certificate of Analysis and detailed characterisation data (BET, mercury porosimetry, ICP-MS trace metals, PSD) available on request.

    Available modifications

    Bonded phases on Exsil Avanti BDS.

    Reversed-phase and polar chemistries built on the same base-deactivated Type B silica.

    Reversed Phase

    • C18
    • C8
    • Phenyl
    • Fluoro
    • ALKAM
    • QUATTRO

    Polar / Normal Phase

    • CN
    • Silica
    Explore full bonded-phase portfolio

    Typical applications

    Where Exsil Avanti BDS is used.

    Pharmaceutical quality control

    Routine QC methods for basic drug substances and finished pharmaceutical products.

    Basic APIs

    Reliable retention and peak shape for basic active pharmaceutical ingredients.

    Amines

    Symmetrical peaks for primary, secondary and tertiary amines that otherwise tail on Type A silicas.

    Alkaloids

    Well-behaved separations of natural-product alkaloids and related basic compounds.

    Drug impurity analysis

    Consistent selectivity for related-substance and impurity-profiling methods.

    Routine analytical HPLC

    A dependable base-deactivated workhorse for daily analytical HPLC.

    Performance evidence

    Performance evidence

    Real chromatograms, batch-consistency plots, SEM images and particle-size distribution data for Exsil Avanti BDS will be added here as they are released. Full application notes and raw data available on request.

    Application note

    Coming soon

    Chromatograms for basic compounds

    Representative separations of basic APIs, amines and alkaloids on Exsil Avanti BDS will be added soon.

    Quality data

    Coming soon

    Batch-to-batch consistency

    Surface area, pore volume and pore diameter data across multiple consecutive Exsil Avanti BDS batches will be published here.

    Microscopy

    Coming soon

    SEM images

    Scanning electron micrographs of Exsil Avanti BDS particles will be added to document morphology.

    Particle characterisation

    Coming soon

    Particle size distribution

    PSD data for each grade will be added to support method-transfer decisions.

    Application guidance

    When should you choose Avanti BDS?

    A quick guide to help you decide whether Exsil Avanti BDS is the right silica family for your separation.

    ApplicationRecommended silica
    Basic compounds Exsil Avanti BDS
    Routine QC methods Exsil Avanti BDS
    Method development Exsil Avanti BDS
    Neutral compounds Exsil Avanti BDS
    General reversed-phase methods Exsil Avanti BDS

    Method transfer

    Replacing an established BDS method?

    Looking for an alternative to Thermo Scientific™ Hypersil™ BDS?

    Many laboratories continue to use established base-deactivated silica methods. Our technical team can help identify the closest Exsil Avanti BDS equivalent for your application, so existing separations can be re-established with minimal re-development.

    Contact our chromatography specialists

    Why buy from Exmere

    A silica manufacturer that does not compete with its customers.

    Bulk silica specialist

    40+ years of manufacturing HPLC silica in the UK. We supply the bulk material — you own the finished product.

    OEM neutral

    Column-packing customers can specify Exsil Avanti BDS without competitive risk.

    Analytical to preparative

    The same base-deactivated silica lineage from analytical grades through to preparative bulk — a single supplier as methods scale.

    FAQ

    Frequently asked questions.

    Next step

    Need help selecting the right base-deactivated silica?

    Whether you are replacing an existing method or developing a new separation for basic compounds, our chromatography specialists are ready to help. Request a quotation, a sample, or technical support — we respond within one business day.

    Request quotation Contact technical support

    Free technical evaluation samples

    Full CoA and characterisation data

    OEM & private-label supply

    Response within one business day

    Exmere Ltd — HPLC Silica Engineering

    Unit 8, Boundary Way, Kellet Road Industrial Estate, Carnforth, Lancashire LA5 9XP, UK

    info@exmere.eu · +44 (0)1524 734451