Exmere

    Ultra-high purity HPLC silica

    Exsil Pure™

    Ultra-high purity Type B silica engineered for reproducible chromatography.

    When chromatographic methods must deliver identical results over years of routine use, silica quality becomes critical. Exsil Pure combines ultra-low metal content, tightly controlled silica synthesis and reproducible bonding technology to deliver excellent peak symmetry, consistent selectivity and outstanding batch-to-batch reproducibility.

    120 Å230 m²/g1.5 µm – 10 µmType B
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    Exsil Pure ultra-high purity spherical Type B silica microspheres
    Ultra-high purity · 120 Å · 1.5 – 10 µm

    Pore size

    120 Å

    Surface area

    230 m²/g

    Pore volume

    0.70 mL/g

    Morphology

    Fully spherical

    Particle sizes

    1.5 µm – 10 µm

    Silica type

    Type B

    Product overview

    Ultra-high purity silica for reproducible HPLC.

    Exsil Pure is a fully spherical Type B HPLC silica with 120 Å pore diameter, 230 m²/g specific surface area and 0.70 mL/g pore volume. Its ultra-low alkali and heavy metal content is designed to minimise the unwanted secondary interactions that can compromise peak shape and method robustness.

    The full bonded-phase portfolio is available across 1.5 µm to 10 µm from a single silica lineage, so methods for pharmaceutical QC, method development and preparative isolation scale predictably from UHPLC screening through to bulk supply.

    RP18
    RP18M
    C18MS
    Biphenyl
    PFP
    Fluoro
    PolaRP
    ALKAM
    Explore all phases

    Why Exsil Pure

    Why chromatographers choose Exsil Pure.

    Ultra-high purity silica

    Ultra-low alkali and heavy metal content minimise unwanted secondary interactions with analytes.

    Batch-to-batch reproducibility

    Controlled silica synthesis ensures highly reproducible pore structure, selectivity and retention.

    Excellent peak symmetry

    Designed to provide excellent peak shapes for acidic, basic and neutral compounds.

    High loading capacity

    Optimised surface chemistry enables efficient loading without compromising chromatographic performance.

    Scalable particle platform

    Available from UHPLC particle sizes through to preparative chromatography media on the same silica lineage.

    Manufactured by Exmere

    Complete control from silica synthesis to finished bonded phase, produced in the UK by Exmere.

    The chemistry

    Why silica purity matters

    Residual metal content is one of the most underestimated variables in HPLC. Here is what it does to a separation — and how Exsil Pure is engineered to minimise it.

    Residual alkali and heavy metal ions retained in the silica matrix can interact with analytes through ion-exchange and chelation mechanisms — in addition to the intended retention on the bonded ligand.

    These unwanted interactions may lead to:

    • Changes in selectivity
    • Peak tailing
    • Reduced method robustness
    • Poor batch reproducibility

    Exsil Pure is engineered with ultra-low metal content and tightly controlled silica synthesis to minimise these effects, so retention, selectivity and peak shape remain reproducible from batch to batch.

    In plain terms

    Cleaner silica, more predictable chromatography.

    Lower alkali and heavy metal content mean fewer secondary interactions. Peaks remain symmetrical, selectivity is easier to reproduce between batches, and validated methods survive routine use with fewer surprises.

    Technical specifications

    Engineered properties.

    Silica typeType B
    Pore size120 Å
    Specific surface area230 m²/g
    Pore volume0.70 mL/g
    Alkali metals< 300 ppb
    Heavy metals< 100 ppb
    MorphologyFully spherical
    Mean particle size1.5 µm, 3 µm, 3.5 µm, 5 µm, 7 µm, 10 µm

    Full Certificate of Analysis and detailed characterisation data (BET, mercury porosimetry, ICP-MS trace metals, PSD) available on request.

    Performance evidence

    Performance evidence

    Real technical figures for Exsil Pure will be added here as they are released. Full application notes and raw data available on request.

    Application note

    Coming soon

    Batch-to-batch reproducibility chromatogram

    Overlaid chromatograms from consecutive Exsil Pure batches will be added here to document reproducibility of retention and selectivity.

    Quality data

    Coming soon

    Physical property consistency

    Surface area, pore volume and pore diameter data across multiple consecutive Exsil Pure batches will be published here.

    Manufacturing consistency

    Reproducibility starts with reproducible silica.

    Exmere controls every critical manufacturing step in-house, so the physical and chemical properties that determine chromatographic performance stay within tight release specifications from batch to batch.

    Silica synthesis

    Controlled synthesis from high-purity precursors sets the baseline chemistry of every batch.

    Pore structure

    Pore size and pore volume are engineered and verified to specification.

    Particle morphology

    Fully spherical particles with a controlled size distribution across all grades.

    Surface chemistry

    Consistent silanol population and metal content on every silica lot.

    Bonding

    Reproducible bonding chemistry to preserve selectivity between batches.

    Batch release testing

    Every batch is characterised and released against defined specifications with a full CoA.

    Available modifications

    Bonded phases on Exsil Pure.

    Reversed-phase and polar chemistries built on the same ultra-high purity Type B silica.

    RP18
    RP18M
    C18MS
    Biphenyl
    PFP
    Fluoro
    PolaRP
    ALKAM
    Explore full bonded-phase portfolio

    Typical applications

    Where Exsil Pure is used.

    Pharmaceutical quality control

    Routine QC methods that must remain reproducible across many production batches and years of use.

    Method development

    A dependable, high-purity starting point for developing robust HPLC methods.

    Analytical HPLC

    Everyday analytical separations where peak symmetry and retention reproducibility matter.

    UHPLC

    Sub-2 µm and 3 µm grades for high-resolution, high-throughput separations.

    Preparative chromatography

    Larger particle grades and bulk supply for scale-up and preparative isolation.

    OEM column manufacturing

    Bulk supply for column packers that require long-term consistency of the underlying silica.

    Why buy from Exmere

    A silica manufacturer that does not compete with its customers.

    Bulk silica specialist

    40+ years of manufacturing HPLC silica in the UK. We supply the bulk material — you own the finished product.

    OEM neutral

    Column-packing customers can specify Exsil Pure without competitive risk.

    Analytical to preparative

    The same ultra-high purity silica lineage from UHPLC grades through to preparative bulk — a single supplier as methods scale.

    FAQ

    Frequently asked questions.

    Next step

    Need help selecting the right ultra-high purity silica?

    Whether you are developing a new method or need long-term bulk supply for column manufacturing, our chromatography specialists are ready to help. Request a quotation, a sample, or technical support — we respond within one business day.

    Request quotation Contact technical support

    Free technical evaluation samples

    Full CoA and characterisation data

    OEM & private-label supply

    Response within one business day

    Exmere Ltd — HPLC Silica Engineering

    Unit 8, Boundary Way, Kellet Road Industrial Estate, Carnforth, Lancashire LA5 9XP, UK

    info@exmere.eu · +44 (0)1524 734451